How CBD Interacts With Medications

Different groups of pill and cannabis leaves

CBD is the new phenomenon of the modern world. In the world where we are trying and discovering new things, CBD can be a total game-changer. However, there is still a lot of research that we need to do on the substance. There are several questions that we get around the consumption of CBD.

Some people want to know what CBD is and how it may work. At the same time, others try to understand how CBD may react with their body. An important question that we get is how CBD interacts with medications.

For example, if you have any chronic illness, you may take some medication to treat it. In that case, if you take CBD, how it may react with you is an important question to look at. The following article will explore the query in detail.

What is CBD?

Cannabis history is well known and widely spread throughout the world. It was used for many medical uses in the previous century. CBD or cannabidiol is the most active substance in the cannabis or hemp plant.

How CBD Works With the Body

CBD is a substance derived from hemp plants. The substance is known to help in treating pains and creates a soothing effect in the human body.

According to the 2019 creaky joints research, an experiment took place where respondents were given CBD to use. Ninety-two percent of these respondents had shown positive results regarding CBD and found the substance user.

cbd oil

Entourage Effects and CBD

Cannabinoids and terpenoids in weeds are thought to collaborate just as the cerebrum’s receptors. This collaboration has been named “the escort impact.” There’s some proof that the impact that makes it by taking THC and CBD together is more successful than either alone.

The escort impact is a proposed instrument by which marijuana compounds other than tetrahydrocannabinol (THC) act synergistically with it to regulate the generally psychoactive impacts of the plant. But CBD does not cause the “high” psychoactive feel by itself.

Understanding Drug Metabolism

Drugs can be metabolized in a number of ways, including oxidation, reduction, hydrolysis, hydration, conjugation, condensation, and isomerization whichever method is used, the objective is to make the drug simpler to excrete.

CBD comes directly from the hemp plant, which is related to its cousin plant, marijuana, or it could be manufactured in a laboratory.

How Is CBD Metabolized When Consumed Orally?

Everything that our body takes orally breaks down and gets absorbed by our body. The absorption of CBD takes place once you take it. It is metabolized through blood once you consume it and transferred to the place where it is needed the most.

CBD and the Cytochrome P450 System

Cytochrome P450 is an enzyme that is mostly responsible for metabolizing the drugs in the human body, including CBD. During the process of absorption, CBD also induces and interferes with CYP3A4. The enzyme is known to absorb all the medications that the human body takes.

Thus, CBD can help in increasing the speed of medicine absorption in the human body.

CBD Interaction With Medications

CBD’s medical benefits have been very popular for the past couple of years. But if you take CBD while taking other medications, then CBD will interact with it differently.

CBD and Ibuprofen

Ibuprofen is an antibiotic that is an anti-inflammatory drug. It produces the same effect for the pain in the body as that of CBD. It was believed that if CBD interacts with ibuprofen, it may have a very negative effect on the body.

However, the research on the interaction of both has shown no such evidence. There is no link that researchers were able to develop between CBD and Ibuprofen. However, it doesn’t mean the interaction does not exist at all. The main reason behind the lack of interaction could be the amount of dosage. Two substances may react if the dosage of substances is increased.

CBD and Adderall

A recent report observed that higher portions of clinical marijuana prompted a diminished utilization of ADHD drugs in grown-ups. Items containing a higher grouping of CBD were connected to bring down ADHD scores.

This implies that CBD can collaborate with ADHD prescriptions, diminishing their adequacy while giving more articulated advantages. The expected results of associations among CBD and Adderall might prompt diminished hunger.

CBD and Lamictal

If you use CBD and Lamictal together, you may experience dizziness. Along with dizziness, you may become drowsy, and it may become difficult to concentrate. The dosage of Lamictal would play a vital role in inducing these symptoms. One may not experience anything at all if the dosage is modest.

CBD Oil and Antibiotics

It is said that if you take antibiotics with CBD, that may amplify the effect of both substances. However, not enough research is available on the matter.

CBD Oil and Omeprazole

CBD can inhibit the enzymes that are targeted by omeprazole and other Proton Pump Inhibitors (PPIs). Taking CBD with certain heartburn medications can increase the risk of diarrhoea.

CBD and Thyroid Medications

Thyroid medication and CBD together can cause nausea in the people who take it together. If both substances are taken together, they may increase the secretion of thyroxin in the body. The increase in substance can make the person feel nauseous.

CBD and Lisinopril

Lisinopril is used to lower blood pressure. CBD, on the other hand, also reduces blood pressure. Thus, if you take them together, you may end up feeling lethargic.

This is because the blood pressure would go down. Consult with your doctor before taking CBD if you are on Lisinopril.

CBD and Prednisone

Since both CBD and corticosteroids are strong inhibitors of the CYP450 chemical framework, it might expand the danger of fundamental after-effects from corticosteroid use because of diminished glucocorticoid freedom. Corticosteroids like prednisone and hydrocortisone ought never to be taken with CBD.

Safety and Side Effects

It is best and is advised to always consult your doctor before starting CBD or a new medication. The doctor can help you monitor any interaction that CBD would have.

There are certain symptoms that you should look for. These are drowsiness, fatigue, nausea, and sedation. If you feel any of these symptoms in your body, visit your doctor.

The type of CBD that you use and the dosage of your medication would be the key factor in determining the interaction between the two. In case of the heavy dosage of medications mentioned above, we strongly recommend you not to take CBD alone.


To conclude, we can say that CBD may or may not react with the medication that you take regularly. In most cases, the interaction of CBD and proposed medication is nil. But that does not mean that it may exist.

We need to understand that a lot of room for research is void in CBD. Current research is not enough to understand accurate interactions. Thus, it is always better to involve a professional while making decisions.

The type of medicine that you take will determine the effect on your body the most. Secondly, look out and adjust the dosages. The dosage of CBD can be decreased than what you take normally. This may help in reaching the point where your CBD does not interact with your medication.

This way, both the substances will go hand in hand. It is also possible that with time you may develop some issues that weren’t there before. Thus, always look for symptoms, and if you catch any of the symptoms mentioned above, then talk with your doctor for further instructions.

Arthur Scott

Arthur finds an interesting niche where he focuses all his energy in. CBD became his happiness, and he boasts of in-depth knowledge about CBD. He later started writing articles about CBD, and it did not take long before his talent was obvious.

He has now secured a permanent position as a writer and CBD consultant in one of the Giant hemp companies. Scott delivers quality and timely content that educates readers on the benefits, and the definition of the best CBD. He spends his leisure time giving hope to patients suffering from neurological conditions.

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